Activation of FGFR3 and its downstream pathways leads to impaired endochondral ossification resulting in short stature. Individuals with hypochondroplasia have different genetic variants in FGFR3 than ...

Three different manifestations of the disease were recognised by microscopic analysis (table 1). Typical signs of AE characterised by endochondral bone formation were similar to those previously ...

1997). However, the mandible differs in this regard; Parada and Chai found that the mandibular body forms through intramembranous ossification, while the condylar process forms through endochondral ...

Researchers hope their discovery about the healing properties of fetal cartilage cells in mice will lay the groundwork for new treatments for human growth disorders and degenerative diseases.

Researchers hope their discovery about the healing properties of fetal cartilage cells in mice will lay the groundwork for new treatments for human growth disorders and degenerative diseases ...

The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be ...

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From the Departments of Medicine and Pathology, The Montreal General Hospital and McGill University (S.C.Y.W., M.F., P.M., A.G.); GenPath Laboratories (A.G.); and ...

RASopathies represent a group of diseases that are increasingly being recognized and studied. Consequently, efforts have been made to improve the quality of life of these patients, in particular the ...

From the Department of Medicine, University of Padova, Padova, Italy (G.P.F., M.R.); Venetian Institute of Molecular Medicine, Padova, Italy (G.P.F.); Department of ...