Epistasis has been used to describe a number of phenomena, including the functional interaction between genes, the genetic outcome of mutations acting within the same genetic pathway, and the ...

ANRIL is the causal gene for CAD at the 9p21.3 locus, and TMEM106B is the causal gene at the 7q21.11 CAD locus. Identification of epistasis is paramount to our understanding of the genetic ...

Interactions between mutations (epistasis) can add substantial complexity to genotype-phenotype maps, hampering our ability to predict evolution. Yet, recent studies have shown that the fitness effect ...

ANRIL is the causal gene for CAD at the 9p21.3 locus, and TMEM106B is the causal gene at the 7q21.11 CAD locus. Identification of epistasis is paramount to our understanding of the genetic ...

Regular quality-assured whole-genome sequencing linked to antimicrobial resistance (AMR) and patient metadata is imperative ...

ROCHESTER, Minnesota — Mayo Clinic researchers recently invented a new class of artificial intelligence (AI) algorithms called hypothesis-driven AI that are a significant departure from ...

Cardiovascular disease is a global health concern and also the leading cause of mortality. Examining how caloric restriction improves cardiovascular health can lead to innovative ways to treat or ...

Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis affecting the mainly axial joints in both East Asia and Europe. To date, the pathogenesis of AS is still unknown, ...

Impact and progress Frontiers' impact Progress Report 2022 All progress reports ...