Figure 5. Epistasis in the mGnRHR double mutant libraries. A histogram depicts the distribution of epistasis scores (ε) for interactions the subset of 251 high quality secondary mutations form with ...

These findings reveal how epistasis is remodeled by conformational defects in membrane proteins and in unstable proteins more generally. Many of the synergistic interactions between mutations within a ...

ROCHESTER, Minnesota — Mayo Clinic researchers recently invented a new class of artificial intelligence (AI) algorithms called hypothesis-driven AI that are a significant departure from ...

Cardiovascular disease is a global health concern and also the leading cause of mortality. Examining how caloric restriction improves cardiovascular health can lead to innovative ways to treat or ...