“It’s not how you want to interface with the gut,” Anikeeva says. “The gut is a lumenal organ—it’s a sock—and the nervous system is distributed in the wall.” In other ...
What distinguishes a protein that is being folded from a terminally misfolded one? How are soluble ER-lumenal substrates retargeted to the ER membrane and how is their insertion into the lipid ...
Proteins enter this compartment as extended polypeptides and fold into their functional state in a process that is assisted by lumenal chaperones such as BiP. The protein folding machinery of the ...