It's long been known that exposure to agricultural pesticides can greatly raise a person's odds for Parkinson's disease. New ...

The study conducted by UCLA Health sheds light on the intricate relationship between genetic variants, pesticide exposure, ...

Published in Science Advances, their research represents a significant step forward in understanding the intricate mechanisms underlying lysosomal calcium regulation—and opens new avenues for ...

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world after Alzheimer’s. Genetic factors account for only a fraction of PD cases, and for decades scientists have ...

Interest in lysosomal storage diseases (LSDs) has increased significantly, because several new therapeutics received FDA approval in 2003. Though long overlooked by most major pharmaceutical ...

Lysosomal Genes Contribute to Parkinson’s Disease near Agriculture with High-Intensity Pesticide Use - ...

"The conclusion of enrollment for Regimen G marks a critical step forward for the HEALEY ALS platform Trial," said Drs. Paganoni and Babu. "We extend our thanks to Denali, academic collaborators, and ...

In the current study, Krainc and his collaborators used live-cell microscopy to investigate the role of VPS13C in regulating ...

This is known as "endosomal escape." Some nanocarriers can open the endo/lysosomal membrane and thus have endosomal escape ...

C-terminal fragments of amyloid precursor protein have been blamed for endolysosomal dysfunction in Alzheimer’s disease. Now, scientists led by Wim Annaert at KU Leuven, Belgium, claim that’s because ...

Malaysia Lysosomal Diseases Association and Fusion Wayang Kulit present a video series highlighting stories of resilience ...

More than 20 years of gene therapy clinical research have led to etranacogene dezaparvovec’s use in hemophilia B, according to authors of a recent review—and it takes its place in a line of current ...