Microtubules tend to grow out from the centrosome to the plasma membrane. In nondividing cells, microtubule networks radiate out from the centrosome to provide the basic organization of the ...

Egg cells are our largest cells. They are so large, in fact, that they should have problems distributing proteins and ...

During anaphase, the central region of the microtubule spindle reorganizes to produce the midzone — an array of antiparallel microtubules essential for cell division. Two studies in Cell have ...

γ-TuRC starting the nucleation process (left) vs. γ-TuRC closing (right). Once closed, thhe foundation is set and tubulins can be added to make the bridge as long as necessary ...

Egg cells are the largest single cells on the planet. Their size—often several to hundreds of times the size of a typical ...

Based on strong overall and progression-free survival data in its Phase III confirmatory study, Pfizer and Genmab’s ...

Recent research has highlighted the role of autophagic function in PD etiology, with mutations in the glucosylceramidase beta ...

Tivdak is a tissue factor-directed antibody and microtubule inhibitor conjugate. The Food and Drug Administration (FDA) has granted full approval to Tivdak ® (tisotumab vedotin-tftv) for the treatment ...

The answer is both surprising and elegant. When DNA inside the nucleus of a human cell is damaged, a specific network of microtubule filaments forms in the cytoplasm around the nucleus and pushes ...

Although motors are required, many relatively basic questions are unanswered. Our laboratory is now focusing on the study of how microtubule asters translocate in cells and position such structures as ...

Destructive Relief. In the proposed strain relief mechanism, left-twisted tau fibrils bind D-peptides, which initially adopt ...

The Phase 2b study planned to be conducted in 15 clinical sites in the United States ---- Topline clinical data expected in the fourth quarter ...