A Phase 2a trial that studied ENV-101's safety and efficacy in adults with mild to moderate IPF showed less lung scarring, ...

"Our research focused on myofibroblasts, a type of kidney cell central to the scarring of renal tissue in fibrosis. By ...

Studies performed during Cycle I of this translational PPG (tPPG) have uncovered a critical role for redox imbalance in activated myofibroblasts (myo-Fbs) that may drive disease progression in IPF. In ...

It is] interesting work that further highlights the complex intercellular crosstalk between stromal cells in cancer,” said ...

During injury or illness, fibroblasts are activated, becoming myofibroblasts that form scar tissue by secreting collagen. When the job is done, these fibroblasts must be deactivated, or de ...

By discovering how a type of smooth muscle—which is essential for mechanical aspects of absorbing fats from food—forms in the ...

In response to fibrogenic influences (for example protracted exposure to ethanol or carbon tetrachloride), they proliferate and transform into myofibroblasts responsible for the deposition of ...

While the San Diego-based biotech awaits a Phase IIa data readout for its lead lung disease candidate, Endeavor BioMedicines' ...

as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. The key mechanism that ensures ...