Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

The non-homologous part of the DNA is un-opened (purple). Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP. 2002. BRCA2 function in DNA binding and ...

CRISPR-Cas9 is effective at generating small mutations by creating targeted double-stranded DNA (dsDNA) breaks that are then repaired by the cell’s non-homologous end-joining pathway.

Ku70 is a DNA repair subunit protein that helps repair DNA via the non-homologous end-joining (NHEJ) pathway. In humans, the ...

Relevant to patients with metastatic castrate-resistant prostate cancer (mCRPC) ...

A specific combination of targeted therapy and immunotherapy may better help patients with non-small cell lung cancer ... have been studying DNA repair by homologous recombination, where the ...

Adding olaparib to maintenance therapy with bevacizumab was associated with significantly longer survival for patients with ...

Such non-allelic homologous recombination (NAHR) can cause chromosome rearrangements. Furthermore, outright failure of DSB repair can lead to meiotic arrest or lethal aneuploidy in gametes. To ...

This interaction suggests that ILF3 may facilitate the resolution of telomeric R-loops, thereby preventing abnormal homologous recombination and maintaining telomere homeostasis. The work ...

It provides Foresight Carrier Screen, a prenatal test for future parents to assess their risk of passing on a recessive genetic condition to their offspring; SneakPeek, a non-invasive blood test ...

The 2022 Inducement Plan is used exclusively for the grant of equity awards to individuals who were not previously employees of Zentalis, or following a bona fide period of non-employment ... Cyclin ...

such as non-small cell lung, bladder, gastric, and esophageal cancers; IDE161, a poly ADP-ribose glycohydrolase inhibitor that is in Phase 1 clinical trial to treat tumors with homologous ...