VEGF stimulates development of the endothelial plexus, while PDGF induces pericyte recruitment to vascular endothelium, facilitating vessel maturation. Dual VEGF/PDGF therapies have been approved ...

Anita became passionate about cardiovascular biology during her time as a visiting student at the Bristol Royal Infirmary, studying pericyte metabolism in Type 2 diabetes. Driven by this enthusiasm, ...

There is evidence that lower doses may be equally effective, especially in patients with less severe edema. [10] If beneficial, neurological improvement can be expected within 48 h with this ...

In this Review, the authors discuss hypoxia signalling and therapeutic strategies targeting this pathway in renal cell carcinoma, with a specific focus on clear cell renal cell carcinoma, in which ...

Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, ...