Indeed, phenformin, an antidiabetic drug that belongs to the same class as metformin, was withdrawn from the market in 1977 because of the high incidence of lactic acidosis associated with its use.

We used a library targeting genes that regulate metabolism and asked the same question as the published paper: which genes regulate sensitivity to the drug phenformin? Our primary T cell screen ...

Psychoses are major mental disorders marked by derangement of personality and loss of contact with reality, and are common in the elderly. Various hypotheses suggest the pivotal role of abnormal ...

Antipsychotics are among the most effective drugs used in psychiatry and reach the level of efficacy common for accepted medications in other fields of medicine. As shown by a number of double ...