Most cases of RA are caused by products of immune cells such as cytokines, bradykinins, or prostanoids invading the synovium—a soft tissue lining the joints—where they bind to damage-sensing ...

Therefore, in the present study, we investigated the effect of resveratrol on the production of prostanoids induced by IL-1β in SK-N-SH cells, a human neuroblastoma cell line. SK-N-SH cells were ...

Colon cancer, is a disease that claims over 900,000 lives annually, is the second leading cause of cancer deaths worldwide.

prostanoids and other autacoids 50. In addition, glucocorticoids transrepress the transcription of nuclear factor-κB (NF-κB)-induced pro-inflammatory genes by inducing the activation of histone ...

Meloxicam is an enolcarboxamide with preferential COX-2 inhibitory activity. In vitro studies with human tissues have confirmed the high affinity of meloxicam for COX-2, whereas COX-1 was ...

which we have found to differ distinctly from a number of other prostanoids. We are currently working to identify the complex pharmacological mechanisms, including characterisation of the prostanoid ...

As an orally available inhibitor of endothelin-1, which has been implicated in the pathogenesis of vascular disease in systemic sclerosis (SSc), bosentan is widely used as first-line therapy for ...

where his research focused on the synthesis and biological evaluation of cyclopentenone prostanoids. After his PhD, Tim spent a few months in the fine chemical sector before returning to academia to ...

Most cases of RA are caused by products of immune cells such as cytokines, bradykinins, or prostanoids invading the synovium--a soft tissue lining the joints--where they bind to damage-sensing ...

New York: In recent years, treatments for rheumatoid arthritis (RA) have advanced significantly. In many situations, a combination of drugs can now effectively suppress the inflammatory cells that ...