A 30-year-old woman was evaluated because of back pain, leg stiffness, and falling. Tone was increased in the legs.

A 72-year-old man who had emigrated from Zimbabwe 20 years previously presented with a 17-year history of swelling of the penis, scrotum, and left leg.

In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and ...

Congenital thrombotic thrombocytopenic purpura (TTP) results from severe hereditary deficiency of ADAMTS13. The efficacy and safety of recombinant ADAMTS13 and standard therapy (plasma-derived ...

In late March 2024, an adult dairy farm worker had onset of redness and discomfort in the right eye. On presentation that day, subconjunctival hemorrhage and thin, serous drainage were noted in ...

Worldwide, cryptococcal meningitis kills up to 180,000 persons annually and is the most common cause of nonviral meningitis in the United States. Besides patients with immunosuppression due to ...

A 63-year-old woman was noted to have white-yellow rings in both eyes. On slit-lamp examination, two concentric rings were seen in each cornea.

In this first episode of a four-part Double Take video miniseries on depression from the New England Journal of Medicine, Dr. Scott-Vernaglia recounts her personal experiences with depression.

A 47-year-old man presented with 2-day history of weakness and fever. Laboratory studies showed pancytopenia. A bone marrow biopsy showed promyelocytes with abundant intracellular rods.

Transcatheter aortic-valve implantation is increasingly used instead of surgical valve replacement, but evidence comparing the two approaches in clinical practice is limited. New research findings ...

Whether infusion of apolipoprotein A1, the primary mediator of cholesterol efflux, can lower the risk of major cardiovascular events after myocardial infarction is unknown. New research findings ...

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