By analyzing the effects genetic variants had on brain cells, they found the cause of a new rare condition—glutamine synthetase stabilization disorder—which causes seizures and delayed ...

SAN DIEGO, May 06, 2024 (GLOBE NEWSWIRE) -- (Nasdaq: LIFE), a clinical stage biotechnology company engaged in the discovery ...

There is no soil activity. The inhibition of the glutamine synthetase enzyme in the effected plant results in the decrease of several amino acids which eventually leads to cell membrane disruption and ...

Phase 3 EFZO-FIT™ study of efzofitimod in pulmonary sarcoidosis expected to complete enrollment in the second quarter of 2024 ...

Table 1 List of fas1genes from different mycobacteria that confer resistance to 5-Cl-PZA in M. smegmatis mc 2 155. Figure 1: 5-Cl-PZA and PZA inhibit Fasi in mycobacteria. Figure 2: PZA inhibits M ...

Alpibectir was developed in a public-private collaboration between GSK, Pasteur Institute Lille, and the University of Lille, and is designed as a companion to ethionamide (Eto), which is an important ...

In addition to the unique codon, one also needs a unique tRNA that will transfer the unnatural amino acid to the growing peptide chain and a corresponding unique aminoacyl-tRNA synthetase to ...

The company is developing ATYR0101, a fusion protein derived from a domain of aspartyl-tRNA synthetase that is in preclinical development for the treatment of fibrosis; and ATYR0750, a domain of ...

Full commercial launch of OLPRUVA at the end of January 2024, with market access growing to ~75% of covered lives as of May 1, 2024 Arimoclomol NDA review underway with PDUFA date of September 21, ...

The company’s lead product candidate is CABA-201, a fully human anti-CD19 binder for the treatment of Phase 1/2 clinical trials in dermatomyositis, anti-synthetase syndrome, immune-mediated ...

Some of the nation's largest superannuation firms are protecting their members from climate risk by dumping thermal coal from ...

Jones et al, Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase, The American Journal of Human Genetics ...