A new study shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can lead to telomere ...

Telomeres must overcome specific challenges to ensure their efficient replication. In yeast cells, telomeres are replicated in late S phase in agreement with the late firing of subtelomeric origins.

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of ...

The length of telomeres in white blood cells, known as leukocytes, varies significantly among sub-Saharan African populations ...

Discoveries about PARP1 biology generate questions that could aid in development of new PARP1-targeting strategies.

A recent study looks at how caloric restriction could help slow down aging processes by reducing the shortening of telomeres, ...

The ends of chromosomes consist of specialized nucleoprotein structures called telomeres that stabilize chromosome ends to help maintain genomic integrity. With each cell division, telomeres ...

Telomeres are tandem repeats of 5'-TTAGGG-3' sequences found at the ends of the chromosomes. Telomeres are essential for ...

However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In this study, researchers used proximity-dependent biotin identification (BioID ...

However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In this study, researchers used proximity-dependent biotin identification (BioID ...

The length of telomeres in white blood cells, known as leukocytes, varies significantly among sub-Saharan African populations, researchers report. Moreover, leukocyte telomere length (LTL) is ...

Roger Reddel, [5] of the Children's Medical Research Institute in Sydney, Australia, is investigating this phenomenon, which is known as "alternative lengthening of telomeres" (ALT). [6] Although ...