Iran’s Supreme Leader Ayatollah Ali Khamenei said he does not expect negotiations with the United States over Tehran’s nuclear program to “reach a conclusion” as Washington toughens its conditions for a deal.

Iran and the United States will hold talks Friday in Rome, their fifth round of negotiations over Tehran’s rapidly advancing nuclear program.

Washington insists that Tehran can’t continue to enrich uranium under a deal, warning that Iran’s ability to do so opens the way for the country to ultimately attain a nuclear weapon, which President...

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